Appetite Stimulation Numerous animal studies have formerly demonstrated that delta-9-THC as well as other cannabinoids have effect that is stimulatory appetite while increasing intake of food. It really is thought that the cannabinoid that is endogenous may serve as a regulator of feeding behavior. The endogenous cannabinoid anandamide potently enhances appetite in mice. Furthermore, CB1 receptors when you look at the hypothalamus might be engaged when you look at the motivational or reward areas of eating. Analgesia Comprehending the apparatus of cannabinoid-induced analgesia happens to be increased through the research of cannabinoid receptors, endocannabinoids, and artificial agonists and antagonists.